Article
The MIF -173G/C polymorphism and risk of childhood acute lymphoblastic leukemia in a Chinese population.
Leukemia research - 1 Oct 2010
Xue Yao, Xu Hongyan, Rong Liucheng, Lu Qin, Li Jie, Tong Na, Wang Meilin, Zhang Zhengdong, Fang Yongjun
Abstract excerpt
Migration inhibitory factor (MIF) has recently been defined as a novel pro-tumorigenic factor that promotes cell proliferation, migration, and invasion. The MIF -173C allele results in increased MIF promoter activity and is associated with a higher serum MIF level. We hypothesized that this polymorphism may contribute to childhood acute lymphoblastic leukemia (ALL) susceptibility. We genotyped the MIF -173G/C...
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