Article
The beta1-adrenergic receptor mediates the pharmacogenetic interaction of the ACE D allele and beta-blockers.
Clinical and translational science - 1 Sept 2008
Ishizawar David C, Janosko Karen M, Teuteberg Jeffrey J, Cadaret Linda M, Mathier Michael A, McNamara Dennis M
Abstract excerpt
The role of beta-receptor selectivity for the interaction between the angiotensin-converting enzyme (ACE) insertion/deletion polymorphism and beta-blocker therapy was investigated in 479 subjects with left ventricular dysfunction. Subjects were separated into no beta-blocker, beta1 -selective, and nonselective beta-blocker treatment groups. The D allele adversely affected transplant-free survival for subjects not...
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