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Article

The potential role of epigenetic modifications in the heritability of multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Feb 2014

Zhou Yuan, Simpson Steve, Holloway Adele F, Charlesworth Jac, van der Mei Ingrid, Taylor Bruce V

Abstract excerpt

It is now well established that both genetic and environmental factors contribute to and interact in the development of multiple sclerosis (MS). However, the currently described causal genetic variants do not explain the majority of the heritability of MS, resulting in 'missing heritability'. Epigenetic mechanisms, which principally include DNA methylation, histone modifications and microRNA-mediated...

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Identifiers

PMID: 24493701
DOI: 10.1177/1352458514520911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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