Article
Dietary arachidonic acid-mediated effects on colon inflammation using transcriptome analysis.
Molecular nutrition & food research - 1 May 2010
Knoch Bianca, Barnett Matthew P G, McNabb Warren C, Zhu Shuotun, Park Zaneta A, Khan Anar, Roy Nicole C
Abstract excerpt
Increased levels of n-6 arachidonic acid (AA), a precursor of pro-inflammatory eicosanoids, have been found in the colon mucosa of inflammatory bowel disease patients when compared with healthy subjects. The hypothesis was that dietary AA would aggravate colon inflammation by changing expression of genes in inflammatory signaling pathways. AA-enriched diet was fed to IL10 gene-deficient (Il10-/-) mice, model of a...
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