Dietary n-6:n-3 PUFA Ratio Modulates Inflammation-Related Gene Expression and Influences Improvements in Biochemical Parameters in a Murine Model of Diet-Induced Obesity

Abstract excerpt

Background: An unbalanced dietary intake of omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFAs) has been associated with chronic inflammation and oxidative stress, both of which contribute to the pathophysiology of obesity. Objective: We aimed to evaluate the effects of a diet with an n-6:n-3 PUFA ratio of 5:1 on body composition, biochemical parameters, and the gene expression of cytokines and...

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