Antimalarial drug resistance and population structure of Plasmodium falciparum in Mozambique using genomic surveillance at health facilities in 2021 and 2022.

doi:10.1038/s41598-025-02166-w

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Antimalarial drug resistance and population structure of Plasmodium falciparum in Mozambique using genomic surveillance at health facilities in 2021 and 2022.

Scientific reports - 11 Aug 2025

Boene Simone, Rovira-Vallbona Eduard, da Silva Clemente, García-Ulloa Manuel, Rafael Bernardete, Canana Neide, Aranda-Díaz Andrés, Cisteró Pau, García-Fernández Carla, Tembisse Dário, Ndimande Nelo, Chidimatembue Arlindo, Matambisso Glória, Palmer Brian, Chico Ana Rita, Dimene Mércia, Saifodine Abuchahama, Inácio José, da Silva Mariana, Plucinski Mateusz, Bonnington Craig, Wate Flavio, de Carvalho Eva, Mathe Guidion, Pujol Arnau, Arregui-Gallego Beatriz, Comiche Kiba, Nhama Abel, Nhamussua Lídia, Aide Pedro, Saute Francisco, Enosse Sónia, Greenhouse Bryan, Candrinho Baltazar, Mayor Alfredo

Abstract excerpt

Monitoring the emergence and spread of drug-resistant parasites is essential for effective malaria control. Here, we describe the prevalence of genetic markers of Plasmodium falciparum antimalarial drug resistance and parasite population structure in Mozambique. Drug resistance loci and microhaplotypes were genotyped by multiplex targeted amplicon sequencing of 1146 P. falciparum samples collected in 2021...

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PMID: 40790052
DOI: 10.1038/s41598-025-02166-w
PMCID: PMC12340125

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