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Article

Role of the GATA-1/FOG-1/NuRD Pathway in the Expression of Human β-Like Globin Genes

4 May 2010

Abstract excerpt

The human beta-globin genes are expressed in a developmentally controlled fashion. Studies on the molecular mechanisms underlying the stage-specific regulation of globin genes have been fueled by the clinical benefit of elevated fetal gamma-globin expression in patients with sickle cell anemia and thalassemia. Recent reports suggested a role of the hematopoietic transcription factor GATA-1, its cofactor FOG-1,...

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Share to Epigenetics and DNA Methylation
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PMID: 20439494
DOI: 10.1128/mcb.00001-10

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Related research

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Role of the GATA-1/FOG-1/NuRD Pathway in the Expression of Human β-Like Globin GenesPMID 20439494Read ↗

Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cellsSemantic proximity Read ↗

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