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Article

Prevalence and clinical course in invasive infections with meningococcal endotoxin variants.

PloS one - 1 Jan 2012

Rodenburg Gerwin D, Fransen Floris, Bogaert Debby, Schipper Kim, Groenwold Rolf H H, Hamstra Hendrik Jan, Westerhuis Brenda M, van de Beek Diederik, van der Ley Peter, Sanders Elisabeth A M, van der Ende Arie

Abstract excerpt

BACKGROUND: Meningococci produce a penta-acylated instead of hexa-acylated lipid A when their lpxL1 gene is inactivated. Meningococcal strains with such lipid A endotoxin variants have been found previously in adult meningitis patients, where they caused less blood coagulopathy because of decreased TLR4 activation. METHODS: A cohort of 448 isolates from patients with invasive meningococcal disease in the...

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Identifiers

PMID: 23209568
DOI: 10.1371/journal.pone.0049295
PMCID: PMC3510230

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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