Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

First appraisal of brain pathology owing to A30P mutant alpha-synuclein.

Annals of neurology - 1 May 2010

Seidel Kay, Schöls Ludger, Nuber Silke, Petrasch-Parwez Elisabeth, Gierga Kristin, Wszolek Zbigniew, Dickson Dennis, Gai Wei P, Bornemann Antje, Riess Olaf, Rami Abdelhaq, Den Dunnen Wilfried F A, Deller Thomas, Rüb Udo, Krüger Rejko

Abstract excerpt

Familial Parkinson disease (PD) due to the A30P mutation in the SNCA gene encoding alpha-synuclein is clinically associated with PD symptoms. In this first pathoanatomical study of the brain of an A30P mutation carrier, we observed neuronal loss in the substantia nigra, locus coeruleus, and dorsa...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to alpha-Synuclein
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Diseases

Share to Family Health

Share to Glial Fibrillary Acidic Protein

Share to Inclusion Bodies

Share to Proline

Source

Identifiers

PMID: 20437567
DOI: 10.1002/ana.21966

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20437567-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

First appraisal of brain pathology owing to A30P mutant alpha-synuclein.PMID 20437567Read ↗

Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers.Semantic proximity Read ↗

Motor impairment and aberrant production of neurochemicals in human alpha-synuclein A30P+A53T transgenic mice with alpha-synuclein pathology.Semantic proximity Read ↗

Novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology.Semantic proximity Read ↗

A Novel SNCA A30G Mutation Causes Familial Parkinson's Disease.Semantic proximity Read ↗

Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function.Semantic proximity Read ↗

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?Semantic proximity Read ↗

Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation.Semantic proximity Read ↗

Mutant protein A30P α-synuclein adopts wild-type fibril structure, despite slower fibrillation kinetics.Semantic proximity Read ↗

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.Semantic proximity Read ↗

Olfactory neuron-specific expression of A30P α-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages.Semantic proximity Read ↗

Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutationSemantic proximity Read ↗

Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.