Abrogation of dominant glucose intolerance in SJL mice by a growth hormone transgene.

doi:10.1677/jme.0.0060129

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Article

Abrogation of dominant glucose intolerance in SJL mice by a growth hormone transgene.

Journal of molecular endocrinology - 1 Apr 1991

Bchini O, Mehtali M, Lathe R

Abstract excerpt

Glucose tolerance was studied in transgenic mice (SJL x C57BL/6) expressing human GH under the control of a housekeeping promoter. Parental SJL mice were found to harbour a dominant allele, termed here glid, determining glucose intolerance in pure-bred animals and in F1 hybrids with glucose-toler...

Topics

Alleles
Animals
Blood Glucose
Genes, Dominant
Glucose Tolerance Test
Growth Hormone
Homeostasis
Humans
Hyperglycemia
Insulin
Insulin Secretion
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Mice, Transgenic
Species Specificity

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