Article
Vitamin D binding protein and monocyte response to 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D: analysis by mathematical modeling.
PloS one - 1 Jan 2012
Chun Rene F, Peercy Bradford E, Adams John S, Hewison Martin
Abstract excerpt
Vitamin D binding protein (DBP) plays a key role in the bioavailability of active 1,25-dihydroxyvitamin D (1,25(OH)(2)D) and its precursor 25-hydroxyvitamin D (25OHD), but accurate analysis of DBP-bound and free 25OHD and 1,25(OH)(2)D is difficult. To address this, two new mathematical models were developed to estimate: 1) serum levels of free 25OHD/1,25(OH)(2)D based on DBP concentration and genotype; 2) the...
Topics
- 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
- Cells, Cultured
- Genotype
- Humans
- Ligands
- Models, Biological
- Models, Theoretical
- Monocytes
- Osmolar Concentration
- Protein Binding
- Receptors, Calcitriol
- Vitamin D
- Vitamin D Response Element
- Vitamin D-Binding Protein