Article
Identification of a paired box gene 8-peroxisome proliferator-activated receptor gamma (PAX8-PPARgamma) rearrangement mosaicism in a patient with an autonomous functioning follicular thyroid carcinoma bearing an activating mutation in the TSH receptor.
Endocrine-related cancer - 1 Sept 2010
Lado-Abeal J, Celestino R, Bravo S B, Garcia-Rendueles M E R, de la Calzada J, Castro I, Castro P, Espadinha C, Palos F, Soares P, Alvarez C V, Sobrinho-Simões M, Cameselle-Teijeiro J
Abstract excerpt
Our main objective was to search for mutations in candidate genes and for paired box gene 8-peroxisome proliferator-activated receptor gamma (PAX8-PPARgamma) rearrangement in a well-differentiated angioinvasive follicular thyroid carcinoma (FTC) causing hyperthyroidism. DNA and RNA were extracted from the patient's thyroid tumor, as well as 'normal' thyroid tissue, and from peripheral blood lymphocytes (PBLs) of...
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