Article
[Pathogenesis of differentiated thyroid cancer (papillary and follicular)].
Arquivos brasileiros de endocrinologia e metabologia - 1 Oct 2005
Maciel Rui M B, Kimura Edna T, Cerutti Janete M
Abstract excerpt
Differentiated thyroid cancers (papillary--PTC and follicular--FTC) are the most common endocrine malignancies. The recent progresses in the understanding of PTC and FTC pathogenesis are summarized in this review. In PTC, a single mutation of BRAF (the gene for the B-type Raf kinase) (V600E) is responsible for the disease in 40-50% of patients, especially in older people and is associated with a poorer...
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