Article
L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
Nephron. Clinical practice - 1 Jan 2010
Yokoyama Keitaro, Urashima Mitsuyoshi, Ohkido Ichiro, Kono Takashi, Yoshida Toyohiko, Muramatsu Masaaki, Niu Tianhua, Hosoya Tatsuo
Abstract excerpt
BACKGROUND AND METHODS: We conducted a large-scale case-control study that explored the association of 358 single nucleotide polymorphisms (SNPs) in 185 patients with end-stage renal disease. A variety of SNPs were recognized as significant in simple association studies. In addition, haplotype analysis identified the gene for the alpha 1C subunit of the voltage-dependent L-type calcium channel (CACNA1C) as having...
Topics
- Calcium Channels, L-Type
- Female
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Hyperparathyroidism, Secondary
- Japan
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Prevalence
- Risk Assessment