Article
Covalent conjugation of the equine infectious anemia virus Gag with SUMO.
Biochemical and biophysical research communications - 6 May 2017
Wang Jinzhong, Wen Shuping, Zhao Rui, Qi Jing, Liu Zhao, Li Weiwei, An Jing, Wood Charles, Wang Ying
Abstract excerpt
The conjugation of small ubiquitin-like modifier (SUMO) to the target protein, namely, SUMOylation, is involved in the regulation of many important biological events including host-pathogen interaction. Some viruses have evolved to exploit the host SUMOylation machinery to modify their own protein. Retroviral Gag protein plays critical roles in the viral life cycle. The HIV-1 p6 and the Moloney murine leukemia...
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