Article

Immunomodulatory Mechanisms of Endoplasmic Reticulum Stress in the Tumor Immune Microenvironment and Prediction of Treatment Response in HER2-Positive Breast Cancer

2026-02-04

Abstract excerpt

<title>Abstract</title> <p> HER2-positive breast cancer (BC) is an aggressive subtype with poor long-term outcomes in advanced disease, largely due to resistance to HER2-targeted therapies. Within the tumor-immune microenvironment (TIME), tumor and immune cells face diverse stressors, including endoplasmic reticulum stress (ERS). ERS activates the Unfolded Protein Response (UPR), which aims to restore homeostasi...

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Literature Corpus work: 2c164dab-8c1f-5ba6-aaf5-495737e84f96
DOI: 10.21203/rs.3.rs-8709304/v1

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