Article
Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2006
Balic Marija, Lin Henry, Young Lillian, Hawes Debra, Giuliano Armando, McNamara George, Datar Ram H, Cote Richard J
Abstract excerpt
PURPOSE: The presence of disseminated tumor cells (DTC) in the bone marrow of breast cancer patients is an acknowledged independent prognostic factor. The biological metastatic potential of these cells has not yet been shown. The presence of putative breast cancer stem cells is shown both in primary tumors and distant metastases. These cells with a CD44(+)CD24(-/low) phenotype represent a minor population in...
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