Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hallmark cellular pathology of Alzheimer's disease induced by mutant human tau expression in cultured Aplysia neurons.

Acta neuropathologica - 1 Aug 2010

Shemesh Or A, Spira Micha E

Abstract excerpt

The mechanisms underlying neurodegenerative diseases are the outcome of pathological alterations of evolutionary conserved molecular and cellular cascades. For this reason, Drosophila and C. elegans serve as useful model systems to study various aspects of neurodegenerative diseases. Here, we introduce the advantageous use of cultured Aplysia neurons (which express over 100 disease-related gene homologs shared...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lysosomes
Share to Microinjections
Share to Microscopy, Electron, Transmission

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microtubule-Associated Proteins

Share to Microtubules

Share to Organelles

Share to Statistics, Nonparametric

Share to tau Proteins

Source

Identifiers

PMID: 20422200
DOI: 10.1007/s00401-010-0689-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hallmark cellular pathology of Alzheimer's disease induced by mutant human tau expression in cultured Aplysia neurons.PMID 20422200Read ↗

Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative diseaseSemantic proximity Read ↗

Selective disruption of Drp1-independent mitophagy and mitolysosome trafficking by an Alzheimer’s disease relevant tau modification in a novelCaenorhabditis elegansmodelSemantic proximity Read ↗

Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model.Semantic proximity Read ↗

Alzheimer's disease and tauopathy studies in flies and worms.Semantic proximity Read ↗

Non-Rodent Genetic Animal Models for Studying Tauopathy: Review of Drosophila, Zebrafish, and C. elegans ModelsSemantic proximity Read ↗

Selective Disruption of Drp1-Independent Mitophagy and Mitolysosome Trafficking by an Alzheimer’s Disease Relevant Tau Modification in a Novel C. elegans ModelSemantic proximity Read ↗

Caenorhabditis elegans Models CountSemantic proximity Read ↗

Insights from Drosophila on Aβ- and tau-induced mitochondrial dysfunction: mechanisms and toolsSemantic proximity Read ↗

Transgenic zebrafish model of neurodegeneration.Semantic proximity Read ↗

Zebrafish as a model organism for neurodegenerative diseaseSemantic proximity Read ↗

Human tNeurons reveal aging-linked proteostasis deficits driving Alzheimer’s phenotypesSemantic proximity Read ↗

Abeta42-Induced Neurodegeneration via an Age-Dependent Autophagic-Lysosomal Injury in DrosophilaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.