Article
Inducible EGFR T790M-mediated gefitinib resistance in non-small cell lung cancer cells does not modulate sensitivity to PI103 provoked autophagy.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jun 2010
Moreira-Leite Flavia F, Harrison Luke R, Mironov Alexandr, Roberts Ruth A, Dive Caroline
Abstract excerpt
INTRODUCTION: Non-small cell lung cancer (NSCLC) with certain activating mutations in the epidermal growth factor receptor (EGFR) is sensitive to the small molecule EGFR tyrosine kinase inhibitors gefitinib and erlotinib, although acquired resistance eventually develops. Resistance is often mediated by acquisition of the T790M mutation in the activated EGFR allele. The aim of this study was to investigate in an...
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