Article
Enhanced cytotoxicity induced by gefitinib and specific inhibitors of the Ras or phosphatidyl inositol-3 kinase pathways in non-small cell lung cancer cells.
International journal of cancer - 1 Jan 2006
Janmaat Maarten L, Rodriguez José A, Gallegos-Ruiz Mariëlle, Kruyt Frank A E, Giaccone Giuseppe
Abstract excerpt
In this study, we have characterized a panel of NSCLC cell lines with differential sensitivity to gefitinib for activating mutations in egfr, pik3ca, and k-ras, and basal protein expression levels of PTEN. The egfr mutant NSCLC cell line H1650 as well as the egfr wild type cell lines H292 and A431 were highly sensitive to gefitinib treatment, indicating that other factors determine gefitinib-sensitivity in egfr...
Topics
- Antibiotics, Antineoplastic
- Antineoplastic Agents
- Carcinoma, Non-Small-Cell Lung
- Cell Death
- Class I Phosphatidylinositol 3-Kinases
- Drug Resistance, Neoplasm
- Enzyme Inhibitors
- ErbB Receptors
- Gefitinib