Article
The afatinib resistance of in vivo generated H1975 lung cancer cell clones is mediated by SRC/ERBB3/c-KIT/c-MET compensatory survival signaling.
Oncotarget - 12 Apr 2016
Booth Laurence, Roberts Jane L, Tavallai Mehrad, Webb Timothy, Leon Daniel, Chen Jesse, McGuire William P, Poklepovic Andrew, Dent Paul
Abstract excerpt
We generated afatinib resistant clones of H1975 lung cancer cells by transient exposure of established tumors to the drug and collected the re-grown tumors. Afatinib resistant H1975 clones did not exhibit any additional mutations in proto-oncogenes when compared to control clones. Afatinib resistant H1975 tumor clones expressed less PTEN than control clones and in afatinib resistant clones this correlated with...
Topics
- Afatinib
- Animals
- Antineoplastic Combined Chemotherapy Protocols
- Cell Line, Tumor
- Cell Survival
- Dasatinib
- Drug Resistance, Neoplasm
- Humans
- Lung Neoplasms
- Mice, Nude
- Mutation
- Proto-Oncogene Proteins c-kit
- Proto-Oncogene Proteins c-met