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Article

The afatinib resistance of in vivo generated H1975 lung cancer cell clones is mediated by SRC/ERBB3/c-KIT/c-MET compensatory survival signaling.

Oncotarget - 12 Apr 2016

Booth Laurence, Roberts Jane L, Tavallai Mehrad, Webb Timothy, Leon Daniel, Chen Jesse, McGuire William P, Poklepovic Andrew, Dent Paul

Abstract excerpt

We generated afatinib resistant clones of H1975 lung cancer cells by transient exposure of established tumors to the drug and collected the re-grown tumors. Afatinib resistant H1975 clones did not exhibit any additional mutations in proto-oncogenes when compared to control clones. Afatinib resistant H1975 tumor clones expressed less PTEN than control clones and in afatinib resistant clones this correlated with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-kit

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Source

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Identifiers

PMID: 26934000
DOI: 10.18632/oncotarget.7746
PMCID: PMC4991406

Genes

ERBB3
KIT
MET
SRC
ATG13
ERBB2
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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