Article
NFE2L2 gene mutation in male Japanese squamous cell carcinoma of the lung.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jun 2010
Sasaki Hidefumi, Hikosaka Yu, Okuda Katsuhiro, Kawano Osamu, Moriyama Satoru, Yano Motoki, Fujii Yoshitaka
Abstract excerpt
INTRODUCTION: Recently, the nuclear factor (erythroid derived 2)-like 2 (NFE2L2) gene mutations were identified in lung cancer. The constitutive activation of NFE2L2 in lung cancer cells promotes tumorigenicity. However, the correlation between NFE2L2 mutation status and clinicopathologic feature...
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