Article
Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation.
Proceedings of the National Academy of Sciences of the United States of America - 11 May 2010
Tyedmers Jens, Treusch Sebastian, Dong Jijun, McCaffery J Michael, Bevis Brooke, Lindquist Susan
Abstract excerpt
When the translation termination factor Sup35 adopts the prion state, [PSI(+)], the read-through of stop codons increases, uncovering hidden genetic variation and giving rise to new, often beneficial, phenotypes. Evidence suggests that prion induction involves a process of maturation, but this has never been studied in detail. To do so, we used a visually tractable prion model consisting of the Sup35 prion domain...
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