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Article

A pure chloride channel mutant of CLC-5 causes Dent's disease via insufficient V-ATPase activation.

Pflugers Archiv : European journal of physiology - 1 Jul 2016

Satoh Nobuhiko, Yamada Hideomi, Yamazaki Osamu, Suzuki Masashi, Nakamura Motonobu, Suzuki Atsushi, Ashida Akira, Yamamoto Daisuke, Kaku Yoshitsugu, Sekine Takashi, Seki George, Horita Shoko

Abstract excerpt

Dent's disease is characterized by defective endocytosis in renal proximal tubules (PTs) and caused by mutations in the 2Cl(-)/H(+) exchanger, CLC-5. However, the pathological role of endosomal acidification in endocytosis has recently come into question. To clarify the mechanism of pathogenesis for Dent's disease, we examined the effects of a novel gating glutamate mutation, E211Q, on CLC-5 functions and...

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Share to Chloride Channels
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27044412
DOI: 10.1007/s00424-016-1808-7

Genes

CLC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A pure chloride channel mutant of CLC-5 causes Dent's disease via insufficient V-ATPase activation.PMID 27044412Read ↗

A novel CLCN5 pathogenic mutation supports Dent disease with normal endosomal acidification.Semantic proximity Read ↗

Heterogeneity in the processing of CLCN5 mutants related to Dent disease.Semantic proximity Read ↗

Novel CLCN5 mutations in patients with Dent's disease result in altered ion currents or impaired exchanger processing.Semantic proximity Read ↗

TMEM9 and SEC22B interact with ClC-5 to shape renal proximal tubule function and Dent’s Disease type I pathogenesisSemantic proximity Read ↗

Direct endosomal acidification by the outwardly rectifying CLC-5 Cl(-)/H(+) exchanger.Semantic proximity Read ↗

ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells.Semantic proximity Read ↗

ClC transporters: discoveries and challenges in defining the mechanisms underlying function and regulation of ClC-5.Semantic proximity Read ↗

Functional and transport analyses of CLCN5 genetic changes identified in Dent disease patients.Semantic proximity Read ↗

ClC-5 mutations associated with Dent's disease: a major role of the dimer interface.Semantic proximity Read ↗

ClC-5 chloride channel and kidney stones: what is the link?Semantic proximity Read ↗

Receptor-mediated endocytosis and endosomal acidification is impaired in proximal tubule epithelial cells of Dent disease patients.Semantic proximity Read ↗

Functional characterization of a novel missense CLCN5 mutation causing alterations in proximal tubular endocytic machinery in Dent's disease.Semantic proximity Read ↗

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