Article
Application of hepatitis B virus replication mouse model.
World journal of gastroenterology - 28 Apr 2010
Gao Zhan, Liu Feng-Jun, Liu Li, Zhou Tao-You, Lei Jun, Xu Lu, Liu Cong, Dai Jie, Chen En-Qiang, Tang Hong
Abstract excerpt
AIM: To evaluate the value of the hepatitis B virus (HBV) replication mouse model with regard to several aspects of the study of HBV biology. METHODS: To evaluate the HBV replication mouse model in detecting the efficacy of anti-HBV agents, the interferon inducer polyinosinic-polytidylin acid (polyIC) and nucleotide analogues adefovir and entecavir were administered to mice injected with wild type pHBV4.1, and...
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