Article
Parkinson's disease: the first common neurological disease due to auto-intoxication?
QJM : monthly journal of the Association of Physicians - 1 Mar 2005
Williams A C, Cartwright L S, Ramsden D B
Abstract excerpt
Parkinson's disease may be a disease of autointoxication. N-methylated pyridines (e.g. MPP+) are well-established dopaminergic toxins, and the xenobiotic enzyme nicotinamide N-methyltransferase (NNMT) can convert pyridines such as 4-phenylpyridine into MPP+, using S-adenosyl methionine (SAM) as the methyl donor. NNMT has recently been shown to be present in the human brain, a necessity for neurotoxicity, because...
Topics
- Brain
- Environment
- Genetic Predisposition to Disease
- Humans
- Inactivation, Metabolic
- Methyltransferases
- Niacinamide
- Nicotinamide N-Methyltransferase
- Parkinson Disease
- Risk Factors
- Xenobiotics