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Article

Pharmacokinetics, pharmacodynamics, and safety of esomeprazole injection/infusion in healthy Chinese volunteers: a five-way crossover study.

Journal of gastroenterology and hepatology - 1 Dec 2013

Yang Hong, Li Jingnan, Zhao Qian, Li Ji, Shen Kai, Yang Xiaoou, Jiang Ji, Hu Pei, Qian Jiaming

Abstract excerpt

BACKGROUND: Esomeprazole provides effective and long lasting inhibition of gastric acid secretion. However, the pharmacokinetics and pharmacodynamics of intravenous esomeprazole in the Chinese population remain unclear. AIM: To compare the pharmacokinetics and pharmacodynamics of intravenous esomeprazole (injection and infusion) and their clinical safety and tolerability in healthy Chinese subjects. METHODS: A...

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PMID: 23800161
DOI: 10.1111/jgh.12305

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