Article
A BRCA1 promoter variant (rs11655505) and breast cancer risk.
Journal of medical genetics - 1 Apr 2010
Verderio Paolo, Pizzamiglio Sara, Southey Melissa C, Spurdle Amanda B, Hopper John L, Chen Xiaoqing, Beesley Jonathan, Schmutzler Rita K, Engel Christoph, Burwinkel Barbara, Bugert Peter, Ficarazzi Filomena, Manoukian Siranoush, Barile Monica, Wappenschmidt Barbara, Chenevix-Trench Georgia, Radice Paolo, Peterlongo Paolo
Abstract excerpt
BACKGROUND: A study of Chinese women recently suggested that the minor allele of rs11655505 in the BRCA1 promoter (c.-2265C-->T) increases promoter activity and has a protective effect on breast cancer risk. METHODS: We genotyped rs11655505 in 2912 female breast cancer cases and 2783 unaffected female controls from four Caucasian breast cancer studies. RESULTS: No evidence for an association between rs11655505...
Read the complete abstract on PubMed