Article
Genetic variants within miR-126 and miR-335 are not associated with breast cancer risk.
Breast cancer research and treatment - 1 Jun 2011
Yang Rongxi, Dick Michelle, Marme Frederik, Schneeweiss Andreas, Langheinz Anne, Hemminki Kari, Sutter Christian, Bugert Peter, Wappenschmidt Barbara, Varon Raymonda, Schott Sarah, Weber Bernhard H F, Niederacher Dieter, Arnold Norbert, Meindl Alfons, Bartram Claus R, Schmutzler Rita K, Müller Heiko, Arndt Volker, Brenner Hermann, Sohn Christof, Burwinkel Barbara
Abstract excerpt
MicroRNAs (miRNAs) are 20-22 nt non-coding RNAs which promote the degradation of target mRNAs or repression of the translation of mRNAs by sequence specific targeting. Many miRNAs are considered as oncogenes or tumor suppressors. MiR-126 and miR-335 play roles in the suppression of breast cancer metastasis by inhibiting tumor growth, proliferation, and cell invasion. The effects of SNPs within the two miRNAs are...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.