Article
NOS3 gene polymorphisms are associated with risk markers of cardiovascular disease, and interact with omega-3 polyunsaturated fatty acids.
Atherosclerosis - 1 Aug 2010
Ferguson Jane F, Phillips Catherine M, McMonagle Jolene, Pérez-Martínez Pablo, Shaw Danielle I, Lovegrove Julie A, Helal Olfa, Defoort Catherine, Gjelstad Ingrid M F, Drevon Christian A, Blaak Ellen E, Saris Wim H M, Leszczyńska-Gołabek Iwona, Kiec-Wilk Beata, Risérus Ulf, Karlström Brita, Lopez-Miranda Jose, Roche Helen M
Abstract excerpt
OBJECTIVE: Omega-3 polyunsaturated fatty acids (n-3 PUFA) may protect against the development of cardiovascular disease (CVD). Genotype at key genes such as nitric oxide synthase (NOS3) may determine responsiveness to fatty acids. Gene-nutrient interactions may be important in modulating the development of CVD, particularly in high-risk individuals with the metabolic syndrome (MetS). METHODS: Biomarkers of CVD...
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