Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MUC1 cytoplasmic domain coactivates Wnt target gene transcription and confers transformation.

Cancer biology & therapy - 1 Jan 2000

Huang Lei, Ren Jian, Chen Dongshu, Li Yongqing, Kharbanda Surender, Kufe Donald

Abstract excerpt

The DF3/MUC1 mucin-like transmembrane oncoprotein is overexpressed by most human carcinomas. The MUC1 cytoplasmic domain (CD) binds directly to the Wnt effector, beta-catenin, and colocalizes with beta-catenin in the nucleus; however, the nuclear function of MUC1 is unknown. The present results demonstrate that MUC1 coactivates transcription of beta-catenin-Tcf-binding sites in the pTOPFLASH reporter. Activation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Cell Transplantation
Share to Clone Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin D1

Share to HCT116 Cells

Share to Luciferases

Share to Mucin-1

Share to Wnt Proteins

Source

Identifiers

PMID: 14688481

Genes

MUC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

MUC1 cytoplasmic domain coactivates Wnt target gene transcription and confers transformation.PMID 14688481Read ↗

MUC1-C Oncoprotein Induces TCF7L2 Transcription Factor Activation and Promotes Cyclin D1 Expression in Human Breast Cancer CellsSemantic proximity Read ↗

MUC1 regulates nuclear localization and function of the epidermal growth factor receptorSemantic proximity Read ↗

Human DF3/MUC1 carcinoma-associated protein functions as an oncogeneSemantic proximity Read ↗

Interaction of the DF3/MUC1 Breast Carcinoma-associated Antigen and β-Catenin in Cell AdhesionSemantic proximity Read ↗

MUC1 drives epithelial–mesenchymal transition in renal carcinoma through Wnt/β-catenin pathway and interaction with SNAIL promoterSemantic proximity Read ↗

MUC1 intra-cellular trafficking is clathrin, dynamin, and rab5 dependent.Semantic proximity Read ↗

MUC4, a Multifunctional Transmembrane Glycoprotein, Induces Oncogenic Transformation of NIH3T3 Mouse Fibroblast CellsSemantic proximity Read ↗

Wnt5a suppresses tumor formation and redirects tumor phenotype in MMTV-Wnt1 tumors.Semantic proximity Read ↗

MUC1 alters oncogenic events and transcription in human breast cancer cellsSemantic proximity Read ↗

Nuclear import of the MUC1-C oncoprotein is mediated by nucleoporin Nup62.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.