Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Roscovitine Inhibits EBNA1 Serine 393 Phosphorylation, Nuclear Localization, Transcription, and Episome Maintenance

6 Jan 2011

Abstract excerpt

Latent Epstein-Barr virus (EBV) infection causes human lymphomas and carcinomas. EBV usually persists as an episome in malignant cells. EBV episome persistence, replication, and gene expression are dependent on EBNA1 binding to multiple cognate sites in oriP. To search for inhibitors of EBNA1- and oriP-dependent episome maintenance or transcription, a library of 40,550 small molecules was screened for compounds...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Protein Tyrosine Phosphatases
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21209116
DOI: 10.1128/jvi.01628-10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Roscovitine Inhibits EBNA1 Serine 393 Phosphorylation, Nuclear Localization, Transcription, and Episome MaintenancePMID 21209116Read ↗

Roscovitine Inhibits Activation of Promoters in Herpes Simplex Virus Type 1 Genomes Independently of Promoter-Specific FactorsSemantic proximity Read ↗

CDK9: A Comprehensive Review of Its Biology, and Its Role as a Potential Target for Anti-Cancer AgentsSemantic proximity Read ↗

Varicella-zoster virus IE63 protein phosphorylation by roscovitine-sensitive cyclin-dependent kinases modulates its cellular localization and activity.Semantic proximity Read ↗

EBNA3C Augments Pim-1 Mediated Phosphorylation and Degradation of p21 to Promote B-Cell ProliferationSemantic proximity Read ↗

Cell-cycle-dependent EBNA1-DNA crosslinking promotes replication termination at oriP and viral episome maintenance.Semantic proximity Read ↗

Targeting EBV Episome for Anti-Cancer Therapy: Emerging Strategies and ChallengesSemantic proximity Read ↗

“The Octet”: Eight Protein Kinases that Control Mammalian DNA ReplicationSemantic proximity Read ↗

When cyclin‐dependent kinases meet viral infections, including SARS‐CoV‐2Semantic proximity Read ↗

USP7 inhibitors disrupt EBNA1 interactome and EBV tumorigenesisSemantic proximity Read ↗

Identification of Herpesvirus Proteins That Contribute to G 1 /S ArrestSemantic proximity Read ↗

Regulation of EBNA1 protein stability and DNA replication activity by PLOD1 lysine hydroxylaseSemantic proximity Read ↗

Roscovitine, a specific inhibitor of cellular cyclin-dependent kinases, inhibits herpes simplex virus DNA synthesis in the presence of viral early proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.