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Article

Probing ligand-binding pockets of the mevalonate pathway enzymes from Streptococcus pneumoniae.

The Journal of biological chemistry - 2 Jul 2010

Lefurgy Scott T, Rodriguez Sofia B, Park Chan Sun, Cahill Sean, Silverman Richard B, Leyh Thomas S

Abstract excerpt

Diphosphomevalonate (Mev.pp) is the founding member of a new class of potential antibiotics targeting the Streptococcus pneumoniae mevalonate (Mev) pathway. We have synthesized a series of Mev.pp analogues designed to simultaneously block two steps in this pathway, through allosteric inhibition o...

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Identifiers

PMID: 20404339
DOI: 10.1074/jbc.M109.098350
PMCID: PMC2898321

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20404339-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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