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Concise Review: Immune Recognition of Induced Pluripotent Stem Cells

14 Mar 2012

Abstract excerpt

Autologous-induced pluripotent stem cells (iPSCs) may eventually be used in cell replacement therapies to treat a wide range of diseases and have been touted as a solution to the vexing problem of immune rejection in this context. Emerging evidence suggests, however, that ostensibly histocompatible iPSCs may be rejected following transplantation. Here, we review the mechanisms that contribute to immunogenicity in...

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PMID: 22419544
DOI: 10.1002/stem.1066

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