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GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination

19 Apr 2010

Abstract excerpt

RAD51 is a key factor in homologous recombination (HR) and plays an essential role in cellular proliferation by repairing DNA damage during replication. The assembly of RAD51 at DNA damage is strictly controlled by RAD51 mediators, including BRCA1 and BRCA2. We found that human RAD51 directly binds GEMIN2/SIP1, a protein involved in spliceosome biogenesis. Biochemical analyses indicated that GEMIN2 enhances the...

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PMID: 20403813
DOI: 10.1093/nar/gkq271

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