Article
Isoenzyme profile of glutathione transferases in transitional cell carcinoma of upper urinary tract.
Translational research : the journal of laboratory and clinical medicine - 1 May 2010
Matic Marija, Simic Tatjana, Dragicevic Dejan, Mimic-Oka Jasmina, Pljesa-Ercegovac Marija, Savic-Radojevic Ana
Abstract excerpt
Upregulated glutathione S-transferase P1 (GSTP1) plays an important role in the resistance to apoptosis in transitional cell carcinoma (TCC) of the urinary bladder (UB) and represents a potential target for chemotherapeutic agents. Our aim was to perform a systematic investigation of a glutathione S-transferase (GST) isoenzyme profile (GSTM, GSTP1, and GSTT1) in the upper urinary tract (UUT) TCC and compare it...
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