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Article

The role of cubilin gene polymorphisms and their influence on 25(OH)D3 and 1,25(OH)2D3 plasma levels in type 1 diabetes patients.

The Journal of steroid biochemistry and molecular biology - 1 Jul 2010

Ramos-Lopez Elizabeth, Lange Brita, Penna-Martinez Marissa, Brück Patrick, Swiech Karolina, Mauf Sabrina, Kahles Heinrich, Badenhoop Klaus

Abstract excerpt

BACKGROUND: Megalin and cubilin bind and internalize the 25(OH)D3-DBP complex in the kidney. Once the complex is internalized, 25(OH)D3 is released and activated to 1,25(OH)2D3 the ligand for the vitamin D receptor (VDR). Supporting the important role of cubilin in this process recent findings showed that cubilin deficiency results in decrease of 25(OH)D3 and 1,25(OH)2D3 plasma levels. METHODS: Two hundred T1D...

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Source

Identifiers

PMID: 20398757
DOI: 10.1016/j.jsbmb.2010.03.087

Genes

DBP
VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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