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Article

Identification of a genetic risk factor for metformin-induced vitamin B12 deficiency.

Diabetologia - 1 Apr 2026

Baldwin Faye D, Bedair Khaled F, Jorgensen Andrea L, Green Lewis, Asiimwe Innocent G, Palmer Colin N A, Campbell Archie, Hayward Caroline, Pan Qing, Shu Shiyu, Li Josephine H, Pearson Ewan R, Pirmohamed Munir, Carr Daniel F

Abstract excerpt

AIMS/HYPOTHESIS: Metformin, a mainstay of treatment for type 2 diabetes, can cause vitamin B12 deficiency. Clinical risk factors have been identified but genetic factors remain undiscovered. Our objective was to identify and validate genetic predisposing factors and establish clinical utility. METHODS: Individuals with metformin-induced vitamin B12 deficiency (n=487) and metformin-tolerant control individuals...

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Identifiers

PMID: 41537778
DOI: 10.1007/s00125-025-06655-5
PMCID: PMC12957035

Genes

CUBN

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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