Article
Monocyte chemoattractant protein-1 blockade inhibits lung cancer tumor growth by altering macrophage phenotype and activating CD8+ cells.
American journal of respiratory cell and molecular biology - 1 Feb 2011
Fridlender Zvi G, Kapoor Veena, Buchlis George, Cheng Guanjun, Sun Jing, Wang Liang-Chuan S, Singhal Sunil, Snyder Linda A, Albelda Steven M
Abstract excerpt
The role of chemokines in the pathogenesis of lung cancer has been increasingly appreciated. Monocyte chemoattractant protein-1 (MCP-1, also known as CCL2) is secreted from tumor cells and associated tumor stromal cells. The blockade of CCL2, as mediated by neutralizing antibodies, was shown to reduce tumorigenesis in several solid tumors, but the role of CCL2 in lung cancer remains controversial, with evidence...
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