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Article

Biomolecular mimicry in the actin cytoskeleton: mechanisms underlying the cytotoxicity of kabiramide C and related macrolides.

Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 2003

Tanaka Junichi, Yan Yuling, Choi Jeongeun, Bai Jihong, Klenchin Vadim A, Rayment Ivan, Marriott Gerard

Abstract excerpt

This study characterizes the interactions between kabiramide C (KabC) and related macrolides and actin and establishes the mechanisms that underlie their inhibition of actin filament dynamics and cytotoxicity. The G-actin-KabC complex is formed through a two-step binding reaction and is extremely stable and long-lived. Competition-binding studies show that KabC binds to the same site on G-actin as Gelsolin domain...

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Identifiers

PMID: 14612571
DOI: 10.1073/pnas.2233339100
PMCID: PMC283510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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