Article
Functional characterization of a mammalian Sac1 and mutants exhibiting substrate-specific defects in phosphoinositide phosphatase activity.
The Journal of biological chemistry - 3 Nov 2000
Nemoto Y, Kearns B G, Wenk M R, Chen H, Mori K, Alb J G, De Camilli P, Bankaitis V A
Abstract excerpt
The Saccharomyces cerevisiae SAC1 gene was identified via independent analyses of mutations that modulate yeast actin function and alleviate the essential requirement for phosphatidylinositol transfer protein (Sec14p) activity in Golgi secretory function. The SAC1 gene product (Sac1p) is an integral membrane protein of the endoplasmic reticulum and the Golgi complex. Sac1p shares primary sequence homology with a...
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