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Article

Identification of genes conferring resistance to 5-fluorouracil

21 Jul 2009

Abstract excerpt

Astrocyte elevated gene-1 (AEG-1) is overexpressed in >90% of human hepatocellular carcinoma (HCC) patients and plays a significant role in mediating aggressive progression of HCC. AEG-1 is known to augment invasion, metastasis, and angiogenesis, and we now demonstrate that AEG-1 directly contributes to another important hallmark of aggressive cancers, that is, resistance to chemotherapeutic drugs, such as...

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PMID: 19622726
DOI: 10.1073/pnas.0901451106

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