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Article

Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms.

Scientific reports - 10 Feb 2016

Rathore Om Singh, Faustino Alexandra, Prudêncio Pedro, Van Damme Petra, Cox Cymon J, Martinho Rui Gonçalo

Abstract excerpt

Protein N-terminal acetylation is an ancient and ubiquitous co-translational modification catalyzed by a highly conserved family of N-terminal acetyltransferases (NATs). Prokaryotes have at least 3 NATs, whereas humans have six distinct but highly conserved NATs, suggesting an increase in regulatory complexity of this modification during eukaryotic evolution. Despite this, and against our initial expectations, we...

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Identifiers

PMID: 26861501
DOI: 10.1038/srep21304
PMCID: PMC4748286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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