Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Blood - 22 Jul 2010
Grimwade David, Hills Robert K, Moorman Anthony V, Walker Helen, Chatters Stephen, Goldstone Anthony H, Wheatley Keith, Harrison Christine J, Burnett Alan K
Abstract excerpt
Diagnostic karyotype provides the framework for risk-stratification schemes in acute myeloid leukemia (AML); however, the prognostic significance of many rare recurring cytogenetic abnormalities remains uncertain. We studied the outcomes of 5876 patients (16-59 years of age) who were classified into 54 cytogenetic subgroups and treated in the Medical Research Council trials. In multivariable analysis,...
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