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Clinical Significance of the Most Common Chromosome Translocations in Adult Acute Myeloid Leukemia

1 Jul 2008

Abstract excerpt

Acquired genetic alterations such as balanced and unbalanced chromosome aberrations and submicroscopic gene mutations and changes in gene expression strongly affect pretreatment features and prognosis of adults with acute myeloid leukemia (AML). The most frequent chromosome/molecular rearrangements, that is, t(8;21)(q22;q22)/RUNX1-RUNX1T1 and inv(16)(p13q22)/t(16;16)(p13;q22)/CBFB-MYH11 characteristic of...

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PMID: 18648004
DOI: 10.1093/jncimonographs/lgn003

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