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Article

Transcriptional regulation of UCP4 by NF-kappaB and its role in mediating protection against MPP+ toxicity.

Free radical biology & medicine - 15 Jul 2010

Ho Jessica Wing-Man, Ho Philip Wing-Lok, Zhang Wei-Yi, Liu Hui-Fang, Kwok Ken Hon-Hung, Yiu David Chi-Wai, Chan Koon-Ho, Kung Michelle Hiu-Wai, Ramsden David Boyer, Ho Shu-Leong

Abstract excerpt

Mitochondrial uncoupling protein-4 (UCP4) enhances neuronal cell survival in MPP(+)-induced toxicity by suppressing oxidative stress and preserving intracellular ATP and mitochondrial membrane potential. UCP4 expression is increased by MPP(+), but its regulation is unknown. Using serial human UCP4 promoter-luciferase reporter gene constructs, we identified and characterized several cis-acting elements that can...

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PMID: 20385226
DOI: 10.1016/j.freeradbiomed.2010.04.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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