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Article

Mechanisms of Resistance to PI3K Inhibitors in Cancer: Adaptive Responses, Drug Tolerance and Cellular Plasticity

26 Mar 2021

Abstract excerpt

The phosphatidylinositol-3-kinase (PI3K) pathway plays a central role in the regulation of several signalling cascades which regulate biological processes such as cellular growth, survival, proliferation, motility and angiogenesis. The hyperactivation of this pathway is linked to tumour progression and is one of the most common events in human cancers. Additionally, aberrant activation of the PI3K pathway has...

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Cancer Mechanisms and Therapy
PI3K/AKT/mTOR signaling in cancer
Protein Degradation and Inhibitors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33810522
DOI: 10.3390/cancers13071538

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