Article
A functional variant in the 3'-UTR of angiopoietin-1 might reduce stroke risk by interfering with the binding efficiency of microRNA 211.
Human molecular genetics - 15 Jun 2010
Chen Jingzhou, Yang Tao, Yu Hui, Sun Kai, Shi Yi, Song Weihua, Bai Yongyi, Wang Xiaojian, Lou Kejia, Song Yan, Zhang Yinhui, Hui Rutai
Abstract excerpt
Angiopoietin-1 is a vascular strengthening factor during vascular development and a protective factor for pathological vascular inflammation and leakage. Brain vascular leaking and inflammation are two important pathological processes of stroke; therefore, we hypothesized that variants of the microRNA-binding site in angiopoietin-1 would affect its expression and confer a risk of stroke. To test our hypothesis, a...
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