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Article

Differential induction of interleukin-10 in monocytes by HIV-1 clade B and clade C Tat proteins.

The Journal of biological chemistry - 11 Jun 2010

Wong Justine K, Campbell Grant R, Spector Stephen A

Abstract excerpt

The clade B human immunodeficiency virus, type 1 (HIV-1) Tat (trans-acting regulatory protein) induces interleukin-10 (IL-10) production in monocytes. IL-10, an anti-inflammatory cytokine, down-regulates proinflammatory cytokines and suppresses the immune response, leading to a rapid progression from HIV-1 infection to AIDS. Nine clades of HIV-1 are responsible for the majority of infections worldwide. Recent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20378550
DOI: 10.1074/jbc.M110.120840
PMCID: PMC2881757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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