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Article

HIV-1 gp120 envelope glycoprotein determinants for cytokine burst in human monocytes

27 Mar 2017

Abstract excerpt

The first step of HIV infection involves the interaction of the gp120 envelope glycoprotein to its receptor CD4, mainly expressed on CD4+ T cells. Besides its role on HIV-1 entry, the gp120 has been shown to be involved in the production of IL-1, IL-6, CCL20 and other innate response cytokines by bystander, uninfected CD4+ T cells and monocytes. However, the gp120 determinants involved in these functions are not...

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PMID: 28346521
DOI: 10.1371/journal.pone.0174550

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